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The structural and functional diversification of the Toxicofera reptile venom system

Fry, Bryan G., Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719, Wüster, Wolfgang, Vidal, Nicolas, Young, Bruce and Jackson, Timothy N.W. (2012) 'The structural and functional diversification of the Toxicofera reptile venom system'. Toxicon, Vol 60, Issue 4, pp. 434-448.

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Abstract

The evolutionary origin and diversification of the reptilian venom system is described. The resolution of higher-order molecular phylogenetics has clearly established that a venom system is ancestral to snakes. The diversification of the venom system within lizards is discussed, as is the role of venom delivery in the behavioural ecology of these taxa (particularly Varanus komodoensis). The more extensive diversification of the venom system in snakes is summarised, including its loss in some clades. Finally, we discuss the contentious issue of a definition for “venom”, supporting an evolutionary definition that recognises the homology of both the venom delivery systems and the toxins themselves.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA.
QV Pharmacology > Toxicology > General Toxicology > QV 600 General works
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.toxicon.2012.02.013
Depositing User: Lynn Roberts-Maloney
Date Deposited: 08 Jan 2015 16:41
Last Modified: 06 Feb 2018 13:08
URI: http://archive.lstmed.ac.uk/id/eprint/4716

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