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Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication]

Ntinginya, E. N., Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Millington, Kerry, Mtafya, B., Saathoff, E., Heinrich, N., Rojas-Ponce, G., Kowuor, D., Maboko, L., Reither, K., Clowes, P., Hoelscher, M. and Rachow, A. (2012) 'Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication]'. International Journal of Tuberculosis and Lung Disease, Vol 16, Issue 11, pp. 1468-1470.

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Abstract

In this pilot study, we evaluated the Xpert® MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7–94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81–100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context.

Item Type: Article
Subjects: QY Clinical Pathology > Diagnostic Tests > QY 120 Sputum
QY Clinical Pathology > QY 25 Laboratory techniques and procedure
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WF Respiratory System > Tuberculosis > WF 205 Epidemiology
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.5588/ijtld.12.0127
Depositing User: Martin Chapman
Date Deposited: 07 Jan 2015 10:55
Last Modified: 06 Feb 2018 13:08
URI: https://archive.lstmed.ac.uk/id/eprint/4718

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