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Cerebral malaria pathogenesis: revisiting parasite and host contributions

Grau, Georges Emile Raymond and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2012) 'Cerebral malaria pathogenesis: revisiting parasite and host contributions'. Future Microbiology, Vol 7, Issue 2, pp. 291-302.

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Abstract

Cerebral malaria is one of a number of clinical syndromes associated with infection by human malaria parasites of the genus Plasmodium. The etiology of cerebral malaria derives from sequestration of parasitized red cells in brain microvasculature and is thought to be enhanced by the proinflammatory status of the host and virulence characteristics of the infecting parasite variant. In this article we examine the range of factors thought to influence the development of Plasmodium falciparum cerebral malaria in humans and review the evidence to support their role.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
QX Parasitology > QX 45 Host-parasite relations
QZ Pathology > Pathogenesis. Etiology > QZ 40 Pathogenesis. Etiology
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.2217/fmb.11.155
Depositing User: Lynn Roberts-Maloney
Date Deposited: 13 Jan 2015 11:10
Last Modified: 06 Feb 2018 13:08
URI: http://archive.lstmed.ac.uk/id/eprint/4728

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