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Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Neafsey, D. E., Waterhouse, R. M., Abai, M. R., Aganezov, S. S., Alekseyev, M. A., Allen, J. E., Amon, J., Arca, B., Arensburger, P., Artemov, G., Assour, L. A., Basseri, H., Berlin, A., Birren, B. W., Blandin, S. A., Brockman, A. I., Burkot, T. R., Burt, A., Chan, C. S., Chauve, C., Chiu, J. C., Christensen, M., Costantini, C., Davidson, V. L. M., Deligianni, E., Dottorini, T., Dritsou, V., Gabriel, S. B., Guelbeogo, W. M., Hall, A. B., Han, M. V., Hlaing, T., Hughes, D. S. T., Jenkins, A. M., Jiang, X., Jungreis, I., Kakani, E. G., Kamali, M., Kemppainen, P., Kennedy, R. C., Kirmitzoglou, I. K., Koekemoer, L. L., Laban, N., Langridge, N., Lawniczak, M. K. N., Lirakis, M., Lobo, N. F., Lowy, E., MacCallum, R. M., Mao, C., Maslen, G., Mbogo, C., McCarthy, J., Michel, K., Mitchell, S. N., Moore, W., Murphy, K. A., Naumenko, A. N., Nolan, T., Novoa, E. M., O'Loughlin, S., Oringanje, C., Oshaghi, M. A., Pakpour, N., Papathanos, P. A., Peery, A. N., Povelones, M., Prakash, A., Price, D. P., Rajaraman, A., Reimer, Lisa ORCID: https://orcid.org/0000-0002-9711-4981, Rinker, D. C., Rokas, A., Russell, T. L., Sagnon, N., Sharakhova, M. V., Shea, T., Simao, F. A., Simard, F., Slotman, M. A., Somboon, P., Stegniy, V., Struchiner, C. J., Thomas, G. W. C., Tojo, M., Topalis, P., Tubio, J. M. C., Unger, M. F., Vontas, J., Walton, C., Wilding, C. S., Willis, J. H., Wu, Y.-C., Yan, G., Zdobnov, E. M., Zhou, X., Catteruccia, F., Christophides, G. K., Collins, F. H., Cornman, R. S., Crisanti, A., Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Emrich, S. J., Fontaine, M. C., Gelbart, W., Hahn, M. W., Hansen, I. A., Howell, P. I., Kafatos, F. C., Kellis, M., Lawson, D., Louis, C., Luckhart, S., Muskavitch, M. A. T., Ribeiro, J. M., Riehle, M. A., Sharakhov, I. V., Tu, Z., Zwiebel, L. J. and Besansky, N. J. (2014) 'Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes'. Science, Vol 347, Issue (6217), p. 1258522.

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Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 460 Genomics. Proteomics
QU Biochemistry > Genetics > QU 470 Genetic structures
QX Parasitology > Protozoa > QX 135 Plasmodia
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1126/science.1258522
Depositing User: Carmel Bates
Date Deposited: 03 Feb 2015 12:52
Last Modified: 06 Feb 2018 13:08
URI: https://archive.lstmed.ac.uk/id/eprint/4843

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