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A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry

Tamarozzi, Francesca, Wright, Helen L., Thomas, Huw B., Edwards, Steven W. and Taylor, Mark (2014) 'A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry'. Immunology Letters, Vol 162, Issue 2 B, pp. 194-198.

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Abstract

We identified IL-17A-positive neutrophils in Wolbachia-positive Onchocerca volvulus nodules using an antibody that has previously reported IL-17A-positive neutrophils in several inflammatory conditions. However, we could not detect IL-17A using a range of alternative assays. Our data question the IL-17A antibody specificity and the ability of human neutrophils to express IL-17A.

Item Type: Article
Subjects: QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1016/j.imlet.2014.10.025
Depositing User: Martin Chapman
Date Deposited: 25 Feb 2015 15:35
Last Modified: 06 Feb 2018 13:08
URI: http://archive.lstmed.ac.uk/id/eprint/4860

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