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Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

Miyajima, F., Swale, A., Zhang, J. E., Alfirevic, A., Little, M., Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791, Smith, G., Kolamunnage-Dona, R. and Pirmohamed, M. (2014) 'Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?'. Clinical Infectious Diseases, Vol 58, Issue 12, e148-e151.

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Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/–251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/–251T >A is unlikely to constitute a major risk factor for CDI.

Item Type: Article
Additional Information: Electronic Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 368 Clostridium infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/cid/ciu152
Depositing User: Lynn Roberts-Maloney
Date Deposited: 13 Apr 2015 08:59
Last Modified: 15 Jun 2018 14:31
URI: http://archive.lstmed.ac.uk/id/eprint/5074

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