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Control lymphocyte subsets: Can one country's values serve for another's?

Mandala, Wilson L., Ananworanich, Jintanat, Apornpong, Tanakorn, Kerr, Stephen J., MacLennan, Jenny M., Hanson, Celine, Jaimulwong, Tanyathip, Gondwe, Esther, Rosenblatt, Howard M., Bunupuradah, Torsak, Molyneux, Malcolm E, Spector, Stephen A., Pancharoen, Chitsanu, Gelman, Rebecca S., MacLennan, Calman A. and Shearer, William T. (2014) 'Control lymphocyte subsets: Can one country's values serve for another's?'. Journal of Allergy and Clinical Immunology, Vol 134, Issue 3, 759-761.e8.

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Abstract

Reliable interpretation of abnormal immunity depends on an understanding of what constitutes “normal.” We and others have reported that lymphocyte patterns are affected by ethnicity, sex, and environmental factors.1-3 Differing exposure to infectious agents, such as malaria, tuberculosis, and cytomegalovirus, could underlie differences in lymphocyte subset patterns in contrasting settings.4-6 In this study we analyzed combined data from 3 studies of healthy children from Thailand,1 Malawi,2 and the United States 3 who had used similar standard flow cytometric methods and markers, thus allowing assessment of immune heterogeneity across settings with differences in ethnicity and infectious disease exposure.

Item Type: Article
Additional Information: Letter to the Editor
Subjects: QU Biochemistry > Cells and Genetics > QU 375 Cell physiology
QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping
QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.jaci.2014.06.030
Depositing User: Lynn Roberts-Maloney
Date Deposited: 17 Jun 2015 08:46
Last Modified: 25 May 2018 14:46
URI: https://archive.lstmed.ac.uk/id/eprint/5208

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