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Positive selection of AS3MT to arsenic water in Andean populations

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Eichstaedt, Christina A., RodriguesAntao, Tiago, Cardona, Alexia, Pagani, Luca, Kivisild, Toomas and Mormina, Maru (2015) 'Positive selection of AS3MT to arsenic water in Andean populations'. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol 780, pp. 97-102.

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Abstract

Arsenic is a carcinogen associated with skin lesions and cardiovascular diseases. The Colla population from the Puna region in Northwest Argentinean is exposed to levels of arsenic in drinking water exceeding the recommended maximum by a factor of 20. Yet, they thrive in this challenging environment since thousands of years and therefore we hypothesize strong selection signatures in genes involved in arsenic metabolism. We analyzed genome-wide genotype data for 730,000 loci in 25 Collas, considering 24 individuals of the neighbouring Calchaquíes and 24 Wichí from the Gran Chaco region in the Argentine province of Salta as control groups. We identified a strong signal of positive selection in the main arsenic methyltransferase AS3MT gene, which has been previously associated with lower concentrations of the most toxic product of arsenic metabolism monomethylarsonic acid. This study confirms recent studies reporting selection signals in the AS3MT gene albeit using different samples, tests and control populations.

Item Type: Article
Additional Information: The original version of this paper can be found at: http://doi.org/10.1016/j.mrfmmm.2015.07.007
Uncontrolled Keywords: Arsenic drinking water; Collas; Puna; Methyltransferase; Calchaquíes
Subjects: QS Anatomy > QS 4 General works. Classify here works on regional anatomy
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.mrfmmm.2015.07.007
Depositing User: Samantha Sheldrake
Date Deposited: 16 Nov 2015 11:33
Last Modified: 02 Feb 2018 16:26
URI: http://archive.lstmed.ac.uk/id/eprint/5401

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