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Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

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Andriessen, Rob, Snetselaar, Janneke, Suer, Remco A., Osinga, Anne J., Deschietere, Johan, Lyimo, Issa N., Mnyone, Ladslaus L., Brooke, Basil D., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Knols, Bart G. J. and Farenhorst, Marit (2015) 'Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes'. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490, Vol 112, Issue 39, pp. 12081-12086.

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Abstract

Insecticide resistance poses a significant and increasing threat to the control of malaria and other mosquito-borne diseases. We present a novel method of insecticide application based on netting treated with an electrostatic coating that binds insecticidal particles through polarity. Electrostatic netting can hold small amounts of insecticides effectively and results in enhanced bioavailability upon contact by the insect. Six pyrethroid-resistant Anopheles mosquito strains from across Africa were exposed to similar concentrations of deltamethrin on electrostatic netting or a standard long-lasting deltamethrin-coated bednet (PermaNet 2.0). Standard WHO exposure bioassays showed that electrostatic netting induced significantly higher mortality rates than the PermaNet, thereby effectively breaking mosquito resistance. Electrostatic netting also induced high mortality in resistant mosquito strains when a 15-fold lower dose of deltamethrin was applied and when the exposure time was reduced to only 5 s. Because different types of particles adhere to electrostatic netting, it is also possible to apply nonpyrethroid insecticides. Three insecticide classes were effective against strains of Aedes and Culex mosquitoes, demonstrating that electrostatic netting can be used to deploy a wide range of active insecticides against all major groups of disease-transmitting mosquitoes. Promising applications include the use of electrostatic coating on walls or eave curtains and in trapping/contamination devices. We conclude that application of electrostatically adhered particles boosts the efficacy of WHO-recommended insecticides even against resistant mosquitoes. This innovative technique has potential to support the use of unconventional insecticide classes or combinations thereof, potentially offering a significant step forward in managing insecticide resistance in vector-control operations.

Item Type: Article
Additional Information: The original version of this paper can be found at: http://doi.org/10.1073/pnas.1510801112
Uncontrolled Keywords: electrostatic coating; insecticide; resistance management; mosquito malaria
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1073/pnas.1510801112
Depositing User: Samantha Sheldrake
Date Deposited: 25 Nov 2015 10:11
Last Modified: 30 Aug 2019 17:06
URI: https://archive.lstmed.ac.uk/id/eprint/5402

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