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A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.

O'Neill, Paul M and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2015) 'A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.'. Angewandte Chemie (International ed. in English), Vol 54, Issue 46, pp. 13504-6.

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Abstract

Putting a stop to malaria: Phenotypic screening against malaria parasites, hit identification, and efficient lead optimization have delivered the preclinical candidate antimalarial DDD107498. This molecule is distinctive in that it has potential for use as a single-dose cure for malaria and shows a unique broad spectrum of activity against the liver, blood, and mosquito stages of the parasite life cycle.

Item Type: Article
Uncontrolled Keywords: antimalarials; drug discovery; inhibitors; lead-optimization; medicinal chemistry
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 744 Pharmaceutical chemistry
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1002/anie.201507264
Depositing User: Mary Creegan
Date Deposited: 27 Jan 2016 15:12
Last Modified: 07 Jun 2018 12:41
URI: https://archive.lstmed.ac.uk/id/eprint/5418

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