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Uniting mathematics and biology for control of visceral leishmaniasis.

Rock, Kat S, le Rutte, Epke A, de Vlas, Sake J, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Medley, Graham F and Hollingsworth, T Deirdre (2015) 'Uniting mathematics and biology for control of visceral leishmaniasis.'. Trends in parasitology, Vol 31, Issue 6, pp. 251-259.

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Abstract

The neglected tropical disease (NTD) visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017 or earlier. To date there is a surprising scarcity of mathematical models capable of capturing VL disease dynamics, which are widely considered central to planning and assessing the efficacy of interventions. The few models that have been developed are examined, highlighting the necessity for better data to parameterise and fit these and future models. In particular, the characterisation and infectiousness of the different disease stages will be crucial to elimination. Modelling can then assist in establishing whether, when, and how the WHO VL elimination targets can be met.

Item Type: Article
Uncontrolled Keywords: visceral leishmaniasis; mathematical model; review; Indian subcontinent; kala-azar
Subjects: WA Public Health > WA 105 Epidemiology
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2015.03.007
Depositing User: Mary Creegan
Date Deposited: 17 Dec 2015 09:27
Last Modified: 15 Jun 2018 10:27
URI: https://archive.lstmed.ac.uk/id/eprint/5452

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