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Serology describes a profile of declining malaria transmission in Farafenni, The Gambia

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van den Hoogen, Lotus L, Griffin, Jamie T, Cook, Jackie, Sepúlveda, Nuno, Corran, Patrick, Conway, David J, Milligan, Paul, Allen, Stephen ORCID: https://orcid.org/0000-0001-6675-249X, Proietti, Carla, Ceesay, Serign J, Targett, Geoffrey A, D'Alessandro, Umberto, Greenwood, Brian, Riley, Eleanor M and Drakeley, Chris (2015) 'Serology describes a profile of declining malaria transmission in Farafenni, The Gambia'. Malaria Journal, Vol 14, Issue 416.

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Abstract

Background
Malaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes.

Methods
Data from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models.

Results
Results showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 % (95 % CI 15–23 %) in 1988 to 1 % (0–2 %) in 2011 (p value for trend in proportions < 0.001) and the SCR dropping from 0.069 year −1 (0.059–0.080) to 0.022 year −1 (0.017–0.028; p = 0.004). The serological data were consistent with previously described drops in both parasite prevalence in children aged 1–5 years (62 %, 57–66 %, in 1988 to 2 %, 0–4 %, in 2011; p < 0.001), and all-cause under five mortality rates (37 per 1000 person-years, 34–41, in 1990 to 17, 15–19, in 2006; p = 0.059).

Conclusions
This analysis shows accurate reconstruction of historical malaria transmission patterns in the Farafenni area using anti-malarial antibody responses. Demonstrating congruence between serological measures, and conventional clinical and parasitological measures suggests broader utility for serology in monitoring and evaluation of malaria transmission.

Item Type: Article
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 570 Serology.
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1186/s12936-015-0939-1
Depositing User: Jessica Jones
Date Deposited: 11 Jan 2016 14:47
Last Modified: 12 Sep 2019 13:28
URI: https://archive.lstmed.ac.uk/id/eprint/5483

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