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Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges

Ferrand, Rashida A, Briggs, Datonye, Ferguson, Jane, Penazzato, Martina, Armstrong, Alice, MacPherson, Peter ORCID: https://orcid.org/0000-0002-0329-9613, Ross, David A and Kranzer, Katharina (2016) 'Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges'. Tropical Medicine & International Health, Vol 21, Issue 3, pp. 325-333.

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Abstract

Objective
Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.

Methods
MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.

Results
From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%.

Conclusion
Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 268.5 Antiviral agents (General)
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy
WS Pediatrics > By Age Groups > WS 460 Adolescence (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1111/tmi.12656
Depositing User: Jessica Jones
Date Deposited: 18 Jan 2016 09:42
Last Modified: 06 Feb 2018 13:11
URI: http://archive.lstmed.ac.uk/id/eprint/5492

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