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One health - an ecological and evolutionary framework for tackling Neglected Zoonotic Diseases.

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Webster, Joanne P, Gower, Charlotte M, Knowles, Sarah C L, Molyneux, David ORCID: https://orcid.org/0000-0001-8537-7947 and Fenton, Andy (2016) 'One health - an ecological and evolutionary framework for tackling Neglected Zoonotic Diseases.'. Evolutionary applications, Vol 9, Issue 2, pp. 313-33.

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Abstract

Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most neglected of all the Neglected Tropical Diseases (NTDs). Here we consider how multihost parasite transmission and evolutionary dynamics may affect the success of human and animal disease control programmes, particularly neglected diseases of the developing world. We review the different types of zoonotic interactions that occur, both ecological and evolutionary, their potential relevance for current human control activities, and make suggestions for the development of an empirical evidence base and theoretical framework to better understand and predict the outcome of such interactions. In particular, we consider whether preventive chemotherapy, the current mainstay of NTD control, can be successful without a One Health approach. Transmission within and between animal reservoirs and humans can have important ecological and evolutionary consequences, driving the evolution and establishment of drug resistance, as well as providing selective pressures for spill-over, host switching, hybridizations and introgressions between animal and human parasites. Our aim here is to highlight the importance of both elucidating disease ecology, including identifying key hosts and tailoring control effort accordingly, and understanding parasite evolution, such as precisely how infectious agents may respond and adapt to anthropogenic change. Both elements are essential if we are to alleviate disease risks from NZDs in humans, domestic animals and wildlife.

Item Type: Article
Uncontrolled Keywords: disease control, ecology, evolution, key hosts, NTDs, NZDs, preventive chemotherapy, zoonoses
Subjects: WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 950 Zoonoses (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1111/eva.12341
Depositing User: Mary Creegan
Date Deposited: 17 Feb 2016 11:57
Last Modified: 31 May 2018 12:42
URI: https://archive.lstmed.ac.uk/id/eprint/5652

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