LSTM Home > LSTM Research > LSTM Online Archive

Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.

Lewis, Joseph ORCID: https://orcid.org/0000-0002-3837-5188, MacPherson, Peter ORCID: https://orcid.org/0000-0002-0329-9613, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Ochodo, Eleanor, Sands, Anita and Taegtmeyer, Miriam ORCID: https://orcid.org/0000-0002-5377-2536 (2015) 'Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.'. AIDS, Vol 29, Issue 18, pp. 2465-2471.

Full text not available from this repository.

Abstract

INTRODUCTION
Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.

METHODS
Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.

RESULTS
Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.

CONCLUSION
Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

Item Type: Article
Subjects: WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.1 Diagnosis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1097/QAD.0000000000000855.
Depositing User: Mary Creegan
Date Deposited: 19 Feb 2016 10:09
Last Modified: 07 Nov 2019 12:00
URI: https://archive.lstmed.ac.uk/id/eprint/5671

Statistics

View details

Actions (login required)

Edit Item Edit Item