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Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors

Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Isaacs, Alison ORCID: https://orcid.org/0000-0002-2452-3338 and Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 (2016) 'Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors'. Trends in Parasitology, Vol 32, Issue 3, pp. 197-206.

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Abstract

Insecticide resistance is a major obstacle to control of Anopheles malaria mosquitoes in sub-Saharan Africa and requires an improved understanding of the underlying mechanisms. Efforts to discover resistance genes and DNA markers have been dominated by candidate gene and quantitative trait locus studies of laboratory strains, but with greater availability of genome sequences a shift toward field-based agnostic discovery is anticipated. Mechanisms evolve continually to produce elevated resistance yielding multiplicative diagnostic markers, co-screening of which can give high predictive value. With a shift toward prospective analyses, identification and screening of resistance marker panels will boost monitoring and programmatic decision making.

Item Type: Article
Subjects: QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2015.12.001
Depositing User: Jessica Jones
Date Deposited: 19 Feb 2016 14:45
Last Modified: 06 Jul 2018 15:00
URI: http://archive.lstmed.ac.uk/id/eprint/5685

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