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A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

Bousfield, Rachel, Thyl, Miliya, Samol, Orng, Rithea, Loet, Sona, Soeng, Chhat, Hor Put, Poda, Sar, Moore, Cartin E., Chheng, Kheng, Kumar, Varun, Day, Nicholas P. J. and Parry, Christopher (2016) 'A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever'. Paediatrics and International Child Health, Vol 36, Issue 2, pp. 118-121.

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Abstract

Background:
Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.
Aims:
To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.
Methods:
In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.
Results:
In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.
Conclusions:
Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

Item Type: Article
Subjects: QY Clinical Pathology > Blood. Blood Chemistry > QY 400 General works
WA Public Health > Health Problems of Special Population Groups > WA 320 Child Welfare. Child Health Services.
WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 270 Typhoid fever
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1179/2046905515Y.0000000009
Depositing User: Jessica Jones
Date Deposited: 03 May 2016 10:03
Last Modified: 06 Feb 2018 13:12
URI: http://archive.lstmed.ac.uk/id/eprint/5867

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