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Addressing resistance to antibiotics in systematic reviews of antibiotic interventions

Leibovici, Leonard, Paul, Mical, Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941, Sinclair, David, Afshari, Arash, Pace, Nathan Leon, Cullum, Nicky, Williams, Hywel C, Smyth, Alan, Skoetz, Nicole, Del Mar, Chris, Schilder, Anne G M, Yahav, Dafna and Tovey, David (2016) 'Addressing resistance to antibiotics in systematic reviews of antibiotic interventions'. Journal of Antimicrobial Chemotherapy, Vol 71, Issue 9, pp. 2367-2369.

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Abstract

Antibiotics are among the most important interventions in healthcare. Resistance of bacteria to antibiotics threatens the effectiveness of treatment. Systematic reviews of antibiotic treatments often do not address resistance to antibiotics even when data are available in the original studies. This omission creates a skewed view, which emphasizes short-term efficacy and ignores the long-term consequences to the patient and other people. We offer a framework for addressing antibiotic resistance in systematic reviews. We suggest that the data on background resistance in the original trials should be reported and taken into account when interpreting results. Data on emergence of resistance (whether in the body reservoirs or in the bacteria causing infection) are important outcomes. Emergence of resistance should be taken into account when interpreting the evidence on antibiotic treatment in randomized controlled trials or systematic reviews.

Item Type: Article
Subjects: QV Pharmacology > Anti-Bacterial Agents. Tissue Extracts > QV 350 Anti-bacterial agents (General or not elsewhere classified)
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/jac/dkw135
Depositing User: Jessica Jones
Date Deposited: 17 May 2016 15:28
Last Modified: 06 Feb 2018 13:12
URI: http://archive.lstmed.ac.uk/id/eprint/5890

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