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HIV and risk of type 2 diabetes in a large adult cohort in Jos, Nigeria.

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Isa, Samson E, Oche, Agbaji O, Kang-ombe, Arthur, Okopi, Joseph A, Idoko, John A, Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 and Gill, Geoff (2016) 'HIV and risk of type 2 diabetes in a large adult cohort in Jos, Nigeria.'. Clinical Infectious Diseases, Vol 63, Issue 6, pp. 830-835.

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Abstract

BACKGROUND
HIV infection and the use of anti-retroviral therapy (ART) may increase the risk of type 2 diabetes mellitus (T2DM). However, data from regions with a high burden of HIV/AIDS is limited. We determined the prevalence of T2DM at the time of presentation to a large HIV Clinic in Nigeria, as well as the incidence of diabetes 12 months following ART initiation.

METHODS
Data from patients enrolled for ART from 2011 to 2013 was analyzed, including 2632 patients on enrollment and 2452 re-evaluated after 12 months of ART commencement. The presence of diabetes, demographic, clinical and biochemical data were retrieved from standardized databases. CD4+, HIV viral load, and hepatitis C virus (HCV) status were noted. Bivariate and logistic regressions were used to identify risk factors for T2DM.

RESULTS
Baseline T2DM prevalence was 2.3% (95%CI: 1.8% - 2.9%), and age, but not body mass index (BMI) was a risk factor for diabetes. After 12 months of ART, a further 5.3% had developed T2DM. Newly developed diabetes was not associated with age, but was associated with BMI. There were no significant associations between prevalent or incident diabetes and CD4+, viral load or type of ART.

CONCLUSIONS
Diabetes is not uncommon in HIV infected individuals at the time of presentation to HIV services. Patients initiating ART then have a high risk of developing diabetes in the first year of ART. Incident diabetes was associated with a BMI≥25.0, and excessive weight gain should be avoided.

Item Type: Article
Subjects: WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
WK Endocrine System > WK 810 Diabetes mellitus
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/cid/ciw381
Depositing User: Jessica Jones
Date Deposited: 17 Jun 2016 15:41
Last Modified: 15 Jun 2018 14:57
URI: https://archive.lstmed.ac.uk/id/eprint/5937

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