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Multi-layered population structure in Island Southeast Asians

Mörseburg, Alexander, Pagani, Luca, Ricaut, Francois-Xavier, Yngvadottir, Bryndis, Harney, Eadaoin, Castillo, Cristina, Hoogervorst, Tom, RodriguesAntao, Tiago, Kusuma, Pradiptajati, Brucato, Nicolas, Cardona, Alexia, Pierron, Denis, Letellier, Thierry, Wee, Joseph, Abdullah, Syafiq, Metspalu, Mait and Kivisild, Toomas (2016) 'Multi-layered population structure in Island Southeast Asians'. European journal of human genetics : EJHG, Vol 24, pp. 1605-1611.

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Abstract

The history of human settlement in Southeast Asia has been complex and involved several distinct dispersal events. Here, we report the analyses of 1825 individuals from Southeast Asia including new genome-wide genotype data for 146 individuals from three Mainland Southeast Asian (Burmese, Malay and Vietnamese) and four Island Southeast Asian (Dusun, Filipino, Kankanaey and Murut) populations. While confirming the presence of previously recognised major ancestry components in the Southeast Asian population structure, we highlight the Kankanaey Igorots from the highlands of the Philippine Mountain Province as likely the closest living representatives of the source population that may have given rise to the Austronesian expansion. This conclusion rests on independent evidence from various analyses of autosomal data and uniparental markers. Given the extensive presence of trade goods, cultural and linguistic evidence of Indian influence in Southeast Asia starting from 2.5 kya, we also detect traces of a South Asian signature in different populations in the region dating to the last couple of thousand years.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QU Biochemistry > Genetics > QU 500 Genetic phenomena
WA Public Health > Health Problems of Special Population Groups > WA 300 General. Refugees
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1038/ejhg.2016.60
Depositing User: Jessica Jones
Date Deposited: 28 Jun 2016 09:11
Last Modified: 06 Feb 2018 13:12
URI: http://archive.lstmed.ac.uk/id/eprint/5939

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