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Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics.

Welburn, Susan C, Molyneux, David ORCID: https://orcid.org/0000-0001-8537-7947 and Maudlin, Ian (2016) 'Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics.'. Trends in parasitology, Vol 32, Issue 3, pp. 230-241.

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Abstract

Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low and cannot account for the catastrophic epidemics of Gambian HAT (gHAT) seen over the past century. Here we examine the origins of gHAT epidemics and evidence implicating human genetics in HAT epidemiology. We discuss the role of stress causing breakdown of heritable tolerance in silent disease carriers generating gHAT outbreaks and see how peculiarities in the epidemiologies of gHAT and Rhodesian HAT (rHAT) impact on strategies for disease control.

Item Type: Article
Uncontrolled Keywords: sleeping sickness; HAT; epidemics; tsetse; famine; epigenetics
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
QX Parasitology > Insects. Other Parasites > QX 505 Diptera
WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2015.11.008
Depositing User: Mary Creegan
Date Deposited: 07 Jul 2016 09:47
Last Modified: 06 Feb 2018 13:12
URI: http://archive.lstmed.ac.uk/id/eprint/5966

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