LSTM Home > LSTM Research > LSTM Online Archive

Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Downloads

Downloads per month over past year

Feasey, Nicholas ORCID: https://orcid.org/0000-0003-4041-1405, Hadfield, James, Keddy, Karen H, Dallman, Timothy J, Jacobs, Jan, Deng, Xiangyu, Wigley, Paul, Barquist Barquist, Lars, Langridge, Gemma C, Feltwell, Theresa, Harris, Simon R, Mather, Alison E, Fookes, Maria, Aslett, Martin, Msefula, Chisomo, Kariuki, Samuel, Maclennan, Calman A, Onsare, Robert S, Weill, François-Xavier, Le Hello, Simon, Smith, Anthony M, McClelland, Michael, Desai, Prerak, Parry, Christopher, Cheesbrough, John, French, Neil, Campos, Josefina, Chabalgoity, Jose A, Betancor, Laura, Hopkins, Katie L, Nair, Satheesh, Humphrey, Tom J, Lunguya, Octavie, Cogan, Tristan A, Tapia, Milagritos D, Sow, Samba O, Tennant, Sharon M, Bornstein, Kristin, Levine, Myron M, Lacharme-Lora, Lizeth, Everett, Dean B, Kingsley, Robert A, Parkhill, Julian, Heyderman, Robert S, Dougan, Gordon, Gordon, Melita A and Thomson, Nicholas R (2016) 'Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.'. Nature Genetics, Vol 48, pp. 1211-1217.

[img]
Preview
Text
Nature_Genetics_48_Distinct salmonella enteritidis lineages.pdf - Accepted Version

Download (8MB) | Preview

Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Item Type: Article
Subjects: QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae
QW Microbiology and Immunology > QW 51 Morphology and variability of microorganisms. Microbial genetics.
WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 269 Salmonella infections
WI Digestive System > WI 140 Diseases (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1038/ng.3644
Depositing User: Jessica Jones
Date Deposited: 20 Sep 2016 13:02
Last Modified: 17 May 2018 09:26
URI: http://archive.lstmed.ac.uk/id/eprint/6161

Statistics

View details

Actions (login required)

Edit Item Edit Item