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Higher expression of somatic repair genes in long-lived ant queens than workers.

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Lucas, Eric ORCID: https://orcid.org/0000-0003-3892-1668, Privman, Eyal and Keller, Laurent (2016) 'Higher expression of somatic repair genes in long-lived ant queens than workers.'. Aging, Vol 8, Issue 9, pp. 1940-1951.

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Abstract

Understanding why organisms senesce is a fundamental question in biology. One common explanation is that senescence results from an increase in macromolecular damage with age. The tremendous variation in lifespan between genetically identical queen and worker ants, ranging over an order of magnitude, provides a unique system to study how investment into processes of somatic maintenance and macromolecular repair influence lifespan. Here we use RNAseq to compare patterns of expression of genes involved in DNA and protein repair of age-matched queens and workers. There was no difference between queens and workers in 1-day-old individuals, but the level of expression of these genes increased with age and this up-regulation was greater in queens than in workers, resulting in significantly queen-biased expression in 2-month-old individuals in both legs and brains. Overall, these differences are consistent with the hypothesis that higher longevity is associated with increased investment into somatic repair.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 475 Genetic processes
QX Parasitology > Insects. Other Parasites > QX 565 Hymenoptera (Bees. Wasps. Ants)
WT Geriatrics. Chronic Disease > Geriatrics > WT 104 Aging process
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.18632/aging.101027
Depositing User: Jessica Jones
Date Deposited: 21 Sep 2016 09:59
Last Modified: 06 Feb 2018 13:13
URI: http://archive.lstmed.ac.uk/id/eprint/6167

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