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Text2PreventCVD: protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases

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Chow, Clara K, Islam, Sheikh Mohammed Shariful, Farmer, Andrew, Bobrow, Kirsty, Maddison, Ralph, Whittaker, Robyn, Dale, Leila Pfaeffli, Lechner, Andreas, Niessen, Louis ORCID: https://orcid.org/0000-0002-8639-5191, Lear, Scott A, Eapen, Zubin J, Santo, Karla, Stepien, Sandrine, Redfern, Julie and Rodgers, Anthony (2016) 'Text2PreventCVD: protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases'. BMJ Open, Vol 6, Issue 10, e012723.

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Abstract

Introduction
Text message interventions have been shown to be effective in prevention and management of several non-communicable disease risk factors. However, the extent to which their effects might vary in different participants and settings is uncertain. We aim to conduct a systematic review and individual participant data (IPD) meta-analysis of randomised clinical trials examining text message interventions aimed to prevent cardiovascular diseases (CVD) through modification of cardiovascular risk factors (CVRFs).

Methods and analysis
Systematic review and IPD meta-analysis will be conducted according to Preferred Reporting Items for Systematic review and Meta-Analysis of IPD (PRISMA-IPD) guidelines. Electronic database of published studies (MEDLINE, EMBASE, PsycINFO and Cochrane Library) and international trial registries will be searched to identify relevant randomised clinical trials. Authors of studies meeting the inclusion criteria will be invited to join the IPD meta-analysis group and contribute study data to the common database. The primary outcome will be the difference between intervention and control groups in blood pressure at 6-month follow-up. Key secondary outcomes include effects on lipid parameters, body mass index, smoking levels and self-reported quality of life. If sufficient data is available, we will also analyse blood pressure and other secondary outcomes at 12 months. IPD meta-analysis will be performed using a one-step approach and modelling data simultaneously while accounting for the clustering of the participants within studies. This study will use the existing data to assess the effectiveness of text message-based interventions on CVRFs, the consistency of any effects by participant subgroups and across different healthcare settings.

Ethics and dissemination
Ethical approval was obtained for the individual studies by the trial investigators from relevant local ethics committees. This study will include anonymised data for secondary analysis and investigators will be asked to check that this is consistent with their existing approvals. Results will be disseminated via scientific forums including peer-reviewed publications and presentations at international conferences.

Trial registration number: CRD42016033236.

Item Type: Article
Subjects: W General Medicine. Health Professions > Health Services. Patients and Patient Advocacy > W 85 Patients. Attitude and compliance
W General Medicine. Health Professions > W 83 Telemedicine (General)
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WG Cardiovascular System > WG 120 Cardiovascular diseases
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1136/bmjopen-2016-012723
Depositing User: Jessica Jones
Date Deposited: 07 Nov 2016 16:02
Last Modified: 30 Aug 2019 17:25
URI: https://archive.lstmed.ac.uk/id/eprint/6341

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