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Prospects for use of interleukin-12 as a mucosal adjuvant for vaccination of humans to protect against respiratory pneumococcal infection

Wright, Adam, Briles, D. E., Metzger, D. W. and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2008) 'Prospects for use of interleukin-12 as a mucosal adjuvant for vaccination of humans to protect against respiratory pneumococcal infection'. Vaccine, Vol 26, Issue 38, pp. 4893-4903.

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Abstract

Mucosal vaccination against pneumococcal disease offers potential protection against otitis media, pneumonia and invasive disease, including providing herd benefit by reducing pathogen carriage. The major obstacle, however, remains the lack of a suitable adjuvant for use in humans. Animal models have demonstrated success of interleukin-12 (IL-12) as an adjuvant for mucosal vaccines using recombinant pneumococcal protein antigens.
This review examines the biology of the IL-12 cytokine family, the toxicity of IL-12 in human studies and suggests approaches by which IL-2 could be developed as a mucosal adjuvant with pneumococcal protein based vaccines, for use in humans. (C) 2008 Published by Elsevier Ltd.

Item Type: Article
Uncontrolled Keywords: mucosal vaccine streptococcus pneumoniae lung recombinant human interleukin-12 renal-cell carcinoma phase-i trial interferon-gamma production chronic hepatitis-c cd4(+) t-cells streptococcus-pneumoniae infection lymphocyte maturation factor innate immune-response conjugate vaccine
Subjects: QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 210 Streptococcal infections (General or not elsewhere classified)
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified)
WV Otolaryngology > Ear > WV 200 General works
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WF Respiratory System > WF 140 Diseases of the respiratory system (General)
Digital Object Identifer (DOI): https://doi.org/10.1016/j.vaccine.2008.06.058
Depositing User: Users 43 not found.
Date Deposited: 22 Jun 2010 11:02
Last Modified: 22 Feb 2018 16:07
URI: https://archive.lstmed.ac.uk/id/eprint/663

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