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Mechanisms of Antimalarial Drug Resistance

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2017) 'Mechanisms of Antimalarial Drug Resistance' in: Meyers, Douglas L., (ed) Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, Volume 1, Cham, Switzerland, Springer, pp. 629-647.

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Abstract

Resistance is the inevitable consequence of chemotherapy. The past decade has seen for the first time in generations, a decline in deaths and morbidity from malaria, largely on account of the use of highly effective antimalarials and the widespread coverage of bed nets and other transmission preventative measures. However over the same period the malaria parasite has assembled even more counter measures than ever before to overcome chemotherapy with some parts of the World reporting clinical failures to artemisinin and artemisinin based combination therapy (ACTs), the cornerstone of current control and elimination strategies. With mortality still at ca. 0.5 million per year, mainly in African children under the age of 5 years old, and the emergence of multi-drug resistant parasites resistant to all known antimalarial drug classes, the need for the development of new drugs which circumvent current parasite resistance mechanisms remains an urgent priority. However, a comprehensive knowledge of drug resistance mechanisms is required to support the development of such strategies. Here we review the latest genetic, biochemical and physiological data that underpin current theories of resistance mechanisms to existing antimalarial drugs.

Item Type: Book Section
Uncontrolled Keywords: Malaria, Plasmodium, drugs, chemotherapy, chloroquine, artemisinin, resistance.
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 254 Antiprotozoal agents (General)
QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1007/978-3-319-46718-4_41
Related URLs:
Depositing User: Martin Chapman
Date Deposited: 05 Jun 2018 12:14
Last Modified: 12 Oct 2018 09:02
URI: http://archive.lstmed.ac.uk/id/eprint/6729

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