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The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species

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Han, Han, Baumann, Kate, Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719, Ali, Syed, Dobson, James, Koludarov, Ivan, Debono, James, Cutmore, Scott C, Rajapakse, Niwanthi W, Jackson, Timothy, Jones, Rob, Hodgson, Wayne C, Fry, Bryan and Kuruppu, Sanjaya (2017) 'The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species'. Toxins, Vol 9, Issue 2, p. 67.

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Abstract

Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10–100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 μg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve‐muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration‐dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post‐synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals.

Item Type: Article
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 405 Marine forms
WG Cardiovascular System > WG 100 General works
WG Cardiovascular System > WG 20 Research (General)
WL Nervous System > WL 140 Nervous system diseases (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.3390/toxins9020067
Depositing User: Stacy Murtagh
Date Deposited: 15 Mar 2017 14:48
Last Modified: 06 Feb 2018 13:14
URI: https://archive.lstmed.ac.uk/id/eprint/6911

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