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A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.

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Duarte, Tonya Azevedo, Nery, Joilda Silva, Boechat, Neio, Pereira, Susan Martins, Simonsen, Vera, Oliveira, Martha, Gomes, Gabriela, Penha-Gonçalves, Carlos, Barreto, Mauricio Lima and Barbosa, Theolis (2017) 'A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.'. The Brazilian journal of infectious diseases, Vol 21, Issue 3, pp. 317-324.

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Abstract

Introduction

The Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.

Methods

EAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.

Results

The EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently reported, with wide distribution of this particular clade described in Brazil. The distribution of other EAI spoligotyping patterns with broader worldwide distribution was restricted to the southeastern region of the country.

Conclusions

EAI may be endemic at a low frequency in Brazil, with some clades indicating increased fitness with respect to this population.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.bjid.2017.01.005
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 31 Mar 2017 10:24
Last Modified: 06 Feb 2018 13:14
URI: http://archive.lstmed.ac.uk/id/eprint/6920

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