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Massive introgression drives species radiation at the range limit of Anopheles gambiae

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Vincente, Jose L, Clarkson, Christopher S, Caputo, Beniamino, Gomes, Bruno ORCID: https://orcid.org/0000-0003-3877-2359, Pombi, Marco, Sousa, Carla A, Antao, Tiago, Dinis, Joao, Botta, Giordano, Manchini, Emiliano, Patrarca, Vincenzo, Mead, Daniel, Drury, Eleanor, Stalker, James, Miles, Alistair, Kwiatkowski, Dominic P, Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Rodrigues, Amabélia, Torre, Alessandra della, Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 and Pinto, Joao (2017) 'Massive introgression drives species radiation at the range limit of Anopheles gambiae'. Scientific Reports, Vol 7, e46451.

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Abstract

Impacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was genetically partitioned into inland and coastal subpopulations, separated by a central region dominated by A. coluzzii. Surprisingly, whole genome sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-like sex chromosome and massive introgression of A. coluzzii autosomal alleles. Local selection on chromosomal inversions may play a role in this process, suggesting potential for spatiotemporal stability of the coastal hybrid form and providing resilience against introgression of medically-important loci and traits, found to be more prevalent in inland A. gambiae.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QU Biochemistry > Genetics > QU 500 Genetic phenomena
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1038/srep46451
Depositing User: Stacy Murtagh
Date Deposited: 27 Apr 2017 11:38
Last Modified: 17 Aug 2018 08:01
URI: https://archive.lstmed.ac.uk/id/eprint/7046

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