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Pneumococcal capsular polysaccharide immunity in the elderly.

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Adler, Hugh ORCID: https://orcid.org/0000-0003-4437-2298, Ferreira, Daniela ORCID: https://orcid.org/0000-0001-7730-9477, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611 (2017) 'Pneumococcal capsular polysaccharide immunity in the elderly.'. Clinical and vaccine immunology : CVI, Vol 24, Issue 6, e00004-17.

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Abstract

Immunity against pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population. Naturally-acquired immunity against pneumococcal capsular polysaccharides develops during childhood and is robust in young adults, but deteriorates with advanced age. In particular, antibody levels and function are reduced in older people. Pneumococcal vaccines are recommended for people over 65 years of age. However, the benefits of polysaccharide and protein-conjugated vaccines in this population are small, due to both serotype replacement and incomplete protection against vaccine-serotype pneumococcal disease. In this review we overview the immune mechanisms by which naturally-acquired and vaccine-induced pneumococcal capsular polysaccharide immunity declines with age, including altered colonization dynamics, reduced opsonic activity of antibodies (particularly IgM) and impaired mucosal immunity.

Item Type: Article
Subjects: QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole.
QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
QW Microbiology and Immunology > QW 52 Physiology and chemistry of microorganisms. Metabolism.
QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WT Geriatrics. Chronic Disease > Geriatrics > WT 100 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1128/CVI.00004-17
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 18 May 2017 09:48
Last Modified: 06 Feb 2018 13:14
URI: http://archive.lstmed.ac.uk/id/eprint/7064

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