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Structure of general-population antibody titer distributions to influenza A virus.

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Nhat, Nguyen Thi Duy, Todd, Stacy, de Bruin, Erwin, Thao, Tran Thi Nhu, Vy, Nguyen Ha Thao, Quan, Tran Minh, Vinh, Dao Nguyen, van Beek, Janko, Anh, Pham Hong, Lam, Ha Minh, Hung, Nguyen Thanh, Thanh, Nguyen Thi Le, Huy, Huynh Le Anh, Ha, Vo Thi Hong, Baker, Stephen, Thwaites, Guy E, Lien, Nguyen Thi Nam, Hong, Tran Thi Kim, Farrar, Jeremy, Simmons, Cameron P, Chau, Nguyen Van Vinh, Koopmans, Marion and Boni, Maciej F (2017) 'Structure of general-population antibody titer distributions to influenza A virus.'. Scientific Reports, Vol 7, Issue 1, p. 6060.

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Abstract

Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.

Item Type: Article
Subjects: QU Biochemistry > Proteins. Amino Acids. Peptides > QU 55 Proteins
QW Microbiology and Immunology > Immunity by Type > QW 563 Local immunity
QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies
WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1038/s41598-017-06177-0
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 22 Aug 2017 10:27
Last Modified: 22 Aug 2017 10:27
URI: https://archive.lstmed.ac.uk/id/eprint/7427

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