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Host response to cytoadherence in Plasmodium falciparum

Chakravorty, S., Hughes, K. R. and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2008) 'Host response to cytoadherence in Plasmodium falciparum'. Biochemical Society Transactions, Vol 36, pp. 221-228.

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Abstract

Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the mechanisms underlying the disease are poorly understood. Endothelial cells have the ability to mobilize immune and pro-adhesive responses when exposed to both PRBCs and TNF (tumour necrosis factor). in addition, there is also an up-regulation by PRBCs and TNF and a concurrent down-regulation of a range of genes involved in inflammation and cell death, by PRBCs and TNF. We propose that the balance between positive and negative regulation will contribute to endothelial pathology during malarial infection. Apposition of PRBCs has been shown by a number of groups to activate signalling pathways. This is dependent, at least in part, on the cytoadherence characteristics of the invading isolate, such that the avidity of the PRBC for the receptor on host endothelium is proportional to the level of activation of the signalling pathways. An understanding of the post-adhesive processes produced by cytoadherence may help us to understand the variable pathology seen in malaria and to design appropriate therapies to alleviate severe disease.

Item Type: Article
Uncontrolled Keywords: adhesion endothelium malaria plosmodium falciparum signalling var gene intercellular-adhesion molecule-1 blood-brain-barrier human endothelial-cells human cerebral malaria chondroitin sulfate-a infected erythrocytes var gene in-vitro microvascular endothelium protozoan parasites
Subjects: QU Biochemistry > Cells and Genetics > QU 375 Cell physiology
QW Microbiology and Immunology > Reference Works. General Immunology > QW 504 General works
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1042/BST0360221
Depositing User: Mary Creegan
Date Deposited: 23 Aug 2010 10:00
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/748

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