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Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

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Kohli, Mikashmi, Schiller, Ian, Dendukuri, Nandini, Ryan, Hannah, Dheda, Keertan, Denkinger, Claudia M, Schumacher, Samuel G and Steingart, Karen (2017) 'Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance'. Cochrane Database of Systematic Reviews, Vol 8, CD012768.

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Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

To determine the diagnostic accuracy of Xpert® MTB/RIF for the detection of extrapulmonary TB by site of disease in people suspected of having extrapulmonary TB. The role of Xpert® MTB/RIF would be a replacement for standard practice.

To determine the diagnostic accuracy of Xpert® MTB/RIF for detection of rifampicin resistance in people suspected of having extrapulmonary TB. The role of Xpert® MTB/RIF would be an initial test for replacement for culture-based DST.

We plan to investigate the impact of covariates on heterogeneity in estimates of test accuracy across the included studies.
Detection of extrapulmonary TB

The covariates of interest are: HIV prevalence; condition of the specimen (fresh versus frozen); sample input volume (for liquid specimens); homogenization step (for tissue specimens); smear status of specimen; past history of TB; and prevalence of extrapulmonary TB. In addition, we plan to explore whether the WHO standard operating procedures for a given type of specimen were followed and can explain the observed heterogeneity in accuracy estimates. For TB meningitis we plan to investigate whether the use of a concentration step prior to the use of Xpert® MTB/RIF has an impact on accuracy estimates. In addition, for detection of lymph node TB, pleural TB, and TB meningitis, we plan to adjust accuracy estimates by applying a latent class meta-analysis model to account for the imperfect nature of culture as the reference standard.
Detection of rifampicin resistance detection

The covariate of interest is the prevalence of rifampicin resistance.

Item Type: Article
Subjects: WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis
WF Respiratory System > Tuberculosis > WF 360 Drug therapy
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1002/14651858.cd012768
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 15 Sep 2017 13:20
Last Modified: 22 Nov 2018 10:17
URI: http://archive.lstmed.ac.uk/id/eprint/7530

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