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The immunological mechanisms that control pneumococcal carriage

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Jochems, Simon ORCID: https://orcid.org/0000-0002-4835-1032, Weiser, Jeffrey N., Malley, Richard and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2017) 'The immunological mechanisms that control pneumococcal carriage'. PLoS Pathogens, Vol 13, Issue 12, e1006665.

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Abstract

Colonization of the human nasopharynx by pneumococcus is extremely common and is both the primary reservoir for transmission and a prerequisite for disease. Current vaccines targeting the polysaccharide capsule effectively prevent colonization, conferring herd protection within vaccinated communities. However, these vaccines cover only a subset of all circulating pneumococcal strains and serotype replacement has been observed. Given the success of PCV in preventing colonization in unvaccinated adults within vaccinated communities, reducing nasopharyngeal colonization has become an outcome of interest for novel vaccines. Here, we discuss the immunological mechanisms that control nasopharyngeal colonization with an emphasis on findings from human studies. Increased understanding of these immunological mechanisms is required to identify correlates of protection against colonization which will facilitate the early testing and design of novel vaccines.

Item Type: Article
Subjects: QU Biochemistry > QU 4 General works
WA Public Health > Preventive Medicine > WA 115 Immunization
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1371/journal.ppat.1006665
Depositing User: Stacy Murtagh
Date Deposited: 02 Jan 2018 16:17
Last Modified: 17 Sep 2019 08:54
URI: https://archive.lstmed.ac.uk/id/eprint/7646

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