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Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity

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Donnellan, Samantha, Stone, Vicki, Johnston, Helinor, Giardiello, Marco, Owen, Andrew, Rannard, Steve, Aljayyoussi, Ghaith, Swift, Benjamin, Tran, Lang, Watkins, Craig and Stevenson, Karen (2017) 'Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity'. Journal of Interdisciplinary Nanomedicine, Vol 2, Issue 3, pp. 146-156.

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Abstract

Tuberculosis kills more people worldwide than any other infectious disease. Treatment requires multiple drug therapy administered over long periods (6–24 months). The emergence of multidrug-resistant strains is a major problem, and with few new drugs in the pipeline, a novel modus operandi is urgently required. Solid drug nanoparticles (SDNs), a new development in nanomedicine, offer a fresh therapeutic approach. Here, we show that SDNs are more effective (50-fold) at killing pathogenic mycobacteria than aqueous forms of the same drug and can target mycobacteria internalised by macrophages, where bacilli reside. We demonstrate synthesis of dual and triple drug loaded SDNs, facilitating combination tuberculosis therapy. Our results suggest that by employing SDNs of existing antibiotics, it may be possible to improve drug delivery and therefore reduce drug dosage to lessen side effects and fight drug resistance

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 268 Antitubercular agents. Antitubercular antibiotics
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 268.5 Antiviral agents (General)
QV Pharmacology > Pharmaceutical Processes. Packaging. Labeling > QV 785 Types of pharmaceutical preparations. Dosage forms
WF Respiratory System > WF 20 Research (General)
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 310 Therapy
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1002/jin2.27
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 24 Oct 2017 13:51
Last Modified: 24 Oct 2017 13:51
URI: http://archive.lstmed.ac.uk/id/eprint/7679

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