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A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi.

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Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, Luck, Amy, Jambo, Kondwani, Ferreira, Daniela ORCID: https://orcid.org/0000-0001-7730-9477, Manda-Taylor, Lucinda, Bejon, Philip, Ngwira, Bagrey, Littler, Katherine, Seager, Zoe, Gibani, Malick, Gmeiner, Markus, Roestenberg, Meta and Mlombe, Yohannie (2017) 'A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi.'. Wellcome Open Research, Vol 2, p. 70.

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Abstract

Controlled human infection model (CHIM) studies have pivotal importance in vaccine development, being useful for proof of concept, pathogenesis, down-selection and immunogenicity studies.  To date, however, they have seldom been carried out in low and middle income countries (LMIC), which is where the greatest burden of vaccine preventable illness is found.  This workshop discussed the benefits and barriers to CHIM studies in Malawi.  Benefits include improved vaccine effectiveness and host country capacity development in clinical, laboratory and governance domains.  Barriers include acceptability, safety and regulatory issues. The report suggests a framework by which ethical, laboratory, scientific and governance issues may be addressed by investigators considering or planning CHIM in LMIC.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 20.5 Biomedical research
WA Public Health > WA 30 Socioeconomic factors in public health (General)
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WA Public Health > Health Administration and Organization > WA 540 National and state health administration
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General)
WZ History of Medicine. Medical Miscellany > History, By Period, Locality, etc. > WZ 112 Collective biography
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI): https://doi.org/10.12688/wellcomeopenres.12256.1
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 30 Oct 2017 16:57
Last Modified: 30 Oct 2017 16:57
URI: http://archive.lstmed.ac.uk/id/eprint/7733

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