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Evidence-based guidelines for supportive care of patients with Ebola virus disease

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Lamontagne, Francois, Fowler, Robert, Adhikari, Neill, Murthy, Srinivas, Brett-Major, David, Jacobs, Michael, Uyeki, Timothy, Vallenas, Constanza, Norris, Susan, Fischer, William, Fletcher, Tom, Levine, Adam, Reed, Paul, Bausch, Daniel, Gove, Sandy, Hall, Andrew, Shepherd, Susan, Siemieniuk, Reed, Lamah, Marie-Claude, Kamara, , Rashida, Nakyeyune, Phiona, Soka, Moses, Edwin, Ama, Hazzan, Afeez, Jacob, Shevin, Elkarsany, Mubarak Mustafa, Adachi, Takuya, Benhadj, Lynda, Clément, Christophe, Crozier, Ian, Garcia, Armando, Hoffman, Steven and Guyatt, Gordon (2018) 'Evidence-based guidelines for supportive care of patients with Ebola virus disease'. Lancet, Vol 391, Issue 10121, pp. 700-708.

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Abstract

The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa was associated with unprecedented challenges in the provision of care to EVD patients, including lack of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care due to fear of a high risk of mortality in treatment units, lack of effective Ebola virus-specific therapy and limitations in provision of supportive medical care. Case fatality rates (CFR) in West Africa were initially greater than 70% but over time decreased with increasing clinical and health system experience that included improvements in supportive care. To inform optimal care in a future EVD outbreak, we employed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to develop evidence-informed guidelines for the delivery of supportive care to patients admitted to Ebola treatment units.

Item Type: Article
Subjects: W General Medicine. Health Professions > Health Services. Patients and Patient Advocacy > W 84.4 Quality of Health Care
W General Medicine. Health Professions > Health Services. Patients and Patient Advocacy > W 84 Health services. Delivery of health care
WA Public Health > WA 30 Socioeconomic factors in public health (General)
WA Public Health > Health Administration and Organization > WA 525 General works
WA Public Health > Health Administration and Organization > WA 530 International health administration
WA Public Health > Health Administration and Organization > WA 540 National and state health administration
WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 534 Viral hemorrhagic fevers
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1016/S0140-6736(17)31795-6
Depositing User: Stacy Murtagh
Date Deposited: 24 Oct 2017 08:55
Last Modified: 17 Apr 2018 01:02
URI: http://archive.lstmed.ac.uk/id/eprint/7737

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