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Recent highlights in antimalarial drug resistance and chemotherapy research

Fidock, D. A., Eastman, R. T., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Meshnick, S. R. (2008) 'Recent highlights in antimalarial drug resistance and chemotherapy research'. Trends in Parasitology, Vol 24, Issue 12, pp. 537-544.

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Abstract

This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters on this topic that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008 (MAM 2008). After surveying this area of research, we focus on two important questions: what is the molecular contribution of pfcrt to chloroquine resistance, and what is the mechanism of action of artemisinin? We conclude with thoughts about the current state of antimalarial chemotherapy and priorities moving forward.

Item Type: Article
Uncontrolled Keywords: falciparum chloroquine resistance parasite plasmodium-falciparum malaria parasites digestive vacuole dihydroorotate dehydrogenase potent antimalarial pfmdr1 gene infected erythrocytes histone acetylation selective activity
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2008.09.005
Depositing User: Mary Creegan
Date Deposited: 13 Aug 2010 09:21
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/775

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