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Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

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Blockley, Alix, Elliott, David R., Roberts, Adam ORCID: https://orcid.org/0000-0002-0760-3088 and Sweet, Michael (2017) 'Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery'. Diversity, Vol 9, Issue 4, e49.

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Abstract

Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and 2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by “blue gold” drug discovery

Item Type: Article
Additional Information: This article belongs to the Special Issue Diversity of Marine Invertebrate and Seaweed Symbiotic Bacteria
Subjects: QV Pharmacology > QV 4 General works
QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole.
QW Microbiology and Immunology > QW 51 Morphology and variability of microorganisms. Microbial genetics.
QW Microbiology and Immunology > Environmental Microbiology > QW 55 Environmental microbiology
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.3390/d9040049
Depositing User: JISC Pubrouter
Date Deposited: 09 Nov 2017 14:00
Last Modified: 06 Sep 2019 09:34
URI: https://archive.lstmed.ac.uk/id/eprint/7805

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