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Genetic diversity of the African malaria vector Anopheles gambiae

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Miles, Alistair, Harding, Nicholas J., Bottà, Giordano, Clarkson, Christopher S., RodriguesAntao, Tiago, Kozack, Krzysztof, Schrider, Daniel R., Kern, Andrew D., Redmond, Seth, Igor, Sharakov, Pearson, Richard D., Bergey, Christina, Fontaine, Michael C., Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Lawniczak, Mara K. N., Kwiatkowski, Dominic P., Ayala, Diego, Besansky, Nora J., Burt, Austin, Caputo, Beniamino, Torre, Alessandra della, Godfray, H. Charles J., Hahn, Matthew W., Midega, Janet, Neafsey, Daniel E., O'Loughlin, Samantha, Pinto, João, Riehle, Michelle M., Vernick, Kenneth D., Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Wilding, Craig, White, Bradley J., Troco, Arlete D., Diabaté, Abdoulaye, Costantini, Carlo, Rohatgi, Kyanne R., Elissa, Nohal, Coulibaly, Boubacar, Dinis, João, Mbogo, Charles, Bejon, Philip, Mawejje, Henry D., Stalker, Jim, Rockett, Kirk, Drury, Eleanor, Mead, Daniel, Jeffreys, Anna, Hubbart, Christina, Rowlands, Kate, Isaacs, Alison ORCID: https://orcid.org/0000-0002-2452-3338, Jyothi, Dushyanth, Malangone, Cinzia, Vauterin, Paul, Jeffery, Ben, Wright, Ian, Hart, Lee, Kluczynski, Krzysztof, Cornelius, Victoria, MacInnis, Bronwyn, Henrichs, Christa and Giacomantonio, Rachel (2017) 'Genetic diversity of the African malaria vector Anopheles gambiae'. Nature, Vol 552, pp. 96-100.

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Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Item Type: Article
Corporate Authors: The Anopheles gambiae 1000 Genomes Consortium
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1038/nature24995
Depositing User: Daisy Byrne
Date Deposited: 19 Dec 2017 12:35
Last Modified: 06 Jul 2018 14:57
URI: https://archive.lstmed.ac.uk/id/eprint/7972

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