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Converging human and malaria vector diagnostics with data management towards an integrated holistic One Health approach

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Mitsakakis, Knostantinos, Hin, Sebastian, Muller, Pie, Wipf, Nadja, Thomsen, Edward ORCID: https://orcid.org/0000-0003-1136-6430, Coleman, Michael ORCID: https://orcid.org/0000-0003-4186-3526, Zengerie, Roland, Vantas, John and Mavridis, Konstantinos (2018) 'Converging human and malaria vector diagnostics with data management towards an integrated holistic One Health approach'. International Journal of Environmental Research and Public Health, Vol 15, Issue 2, p. 259.

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Abstract

Abstract: Monitoring malaria prevalence in humans as well as vector populations for the presence of Plasmodium is an integral component of effective malaria control and eventually elimination. In the field of human diagnostics a major challenge is the ability to define precisely the causative agent of fever, thereby differentiating among several candidate (also non-malaria) febrile diseases. This requires genetic based pathogen identification and multiplexed analysis, which, in combination, are hardly provided by the current diagnostic gold standard tools. In the field of vectors, an essential component of control programs is the detection of Plasmodium species within its mosquito vectors, particularly in the salivary glands where the infective sporozoites reside. In addition, the identification of species composition and insecticide resistance alleles within vector populations is a primary task, in routine monitoring activities, aiming to support control efforts. In this context, the use of converging diagnostics is highly desirable for providing comprehensive information, including differential fever diagnosis in humans and mosquito species composition, infection status and resistance to insecticides of vectors. Nevertheless, the two fields of human diagnostics and vector control are rarely combined, both at the diagnostic and at the data management end, resulting in fragmented data and mis- or non-communication between various stakeholders. To this direction, molecular technologies, their integration in automated platforms, and the co-assessment of data from multiple diagnostic sources through Information and Communication Technologies are possible pathways towards a unified human-vector approach.

Item Type: Article
Additional Information: This article belongs to the Special Issue Malaria Epidemiology and Control: Current Situation and Perspectives
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.3390/ijerph15020259
Depositing User: Stacy Murtagh
Date Deposited: 05 Feb 2018 10:59
Last Modified: 08 Feb 2018 09:33
URI: https://archive.lstmed.ac.uk/id/eprint/8118

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