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Comparison of the first whole genome sequence of ‘Haemophilus quentini’ with two new strains of ‘Haemophilus quentini’ and other Haemophilus species

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Hubbard, Alasdair ORCID: https://orcid.org/0000-0001-6668-9179, Davies, Sian, Baxter, Laura, Thompson, Sarah, Collery, Mark, Hand, Daniel, Thomas, Daniel John and Fink, Colin (2018) 'Comparison of the first whole genome sequence of ‘Haemophilus quentini’ with two new strains of ‘Haemophilus quentini’ and other Haemophilus species'. Genome, Vol 61, Issue 5, pp. 379-385.

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Abstract

Comparison of the genome of the Gram negative human pathogen Haemophilus quentini MP1 with other Haemophilus species revealed that, although it is more closely related to Haemophilus haemolyticus than Haemophilus influenzae, the pathogen is in fact genetically distinct, a finding confirmed by phylogenetic analysis using the H. influenzae multilocus sequence typing genes. Further comparison with two other H. quentini strains recently identified in Canada revealed that these three genomes are more closely related than any other Haemophilus species, however there is still some sequence variation. There was no evidence of acquired antimicrobial resistance within the H. quentini MP1 genome nor any mutations within the DNA gyrase or topoisomerase IV genes known to confer resistance to fluoroquinolones, which has been previously identified in other H. quentini isolates. We hope by presenting the annotation and genetic comparison of the H. quentini MP1 genome it will aid the future molecular detection of this potentially emerging pathogen via the identification of unique genes that differentiate it from other Haemophilus species.

Item Type: Article
Subjects: QU Biochemistry > QU 4 General works
QU Biochemistry > Genetics > QU 450 General Works
QU Biochemistry > Genetics > QU 460 Genomics. Proteomics
QU Biochemistry > Genetics > QU 470 Genetic structures
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1139/gen-2017-0195
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 22 Mar 2018 12:08
Last Modified: 06 Jul 2018 14:53
URI: http://archive.lstmed.ac.uk/id/eprint/8375

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