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High utility of active tuberculosis case finding in an Ethiopian prison

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Merid, Y., Woldeamanuel, Y., Abebe, M., Datiko, Daniel, Hailu, T., Habtamu, G., Assefa, G., Kempker, R. R., Blumberg, H. M. and Aseffa, A. (2018) 'High utility of active tuberculosis case finding in an Ethiopian prison'. The International Journal of Tuberculosis and Lung Disease, Vol 22, Issue 5, pp. 524-529.

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Abstract

SETTING: Hawassa Prison, Southern Region of Ethiopia.
OBJECTIVE: To determine the burden of pulmonary tuberculosis (TB) using active case finding among prisoners.
DESIGN: In this cross-sectional study, prisoners were screened for TB using a symptom screen. Those with cough of 2 weeks had spot and morning sputum samples collected for acid-fast bacilli (AFB) smear microscopy and molecular diagnostic testing (Xpert® MTB/RIF).
RESULTS: Among 2068 prisoners, 372 (18%) had a positive cough screen. The median age of these 372 persons was 23 years, 97% were male and 63% were from urban areas. Among those with a positive symptom screen, 8 (2%) were AFB sputum smear-positive and 31 (8%) were Xpert-positive. The point prevalence of pulmonary TB at the prison was 1748 per 100 000 persons. In multivariate analysis, persons with cough >4 weeks were more likely to have TB (OR 3.34, 95%CI 1.54–7.23).
CONCLUSION: A high prevalence of TB was detected among inmates at a large Ethiopian prison. Active case finding using a cough symptom screen in combination with Xpert had high utility, and has the potential to interrupt transmission of Mycobacterium tuberculosis in correctional facilities in low- and middle-income, high-burden countries.

Item Type: Article
Subjects: WA Public Health > WA 30 Socioeconomic factors in public health (General)
WF Respiratory System > WF 100 General works
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 205 Epidemiology
WF Respiratory System > Tuberculosis > WF 205.1 General coverage
Digital Object Identifer (DOI): https://doi.org/10.5588/ijtld.17.0635
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 26 Apr 2018 14:11
Last Modified: 20 Oct 2018 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/8517

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