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Exploring the origin and degree of genetic isolation of Anopheles gambiae from the islands of Sao Tome and Principe, potential sites for testing transgenic-based vector control

Marshall, J. C., Pinto, J., Charlwood, J. D., Gentile, G., Santolamazza, F., Simard, F., della Torre, A., Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497 and Caccone, A. (2008) 'Exploring the origin and degree of genetic isolation of Anopheles gambiae from the islands of Sao Tome and Principe, potential sites for testing transgenic-based vector control'. Evolutionary Applications, Vol 1, Issue 4, pp. 631-644.

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Abstract

The evolutionary processes at play between island and mainland populations of the malaria mosquito vector Anopheles gambiae sensu stricto are of great interest as islands may be suitable sites for preliminary application of transgenic-based vector control strategies. Sao Tome and Principe, located off the West African coast, have received such attention in recent years. This study investigates the degree of isolation of An. gambiae s.s. populations between these islands and the mainland based on mitochondrial and ribosomal DNA molecular data. We identify possible continental localities from which these island populations derived. For these purposes, we used F-ST values, haplotype networks, and nested clade analysis to estimate migration rates and patterns. Haplotypes from both markers are geographically widespread across the African continent. Results indicate that the populations from Sao Tome and Principe are relatively isolated from continental African populations, suggesting they are promising sites for test releases of transgenic individuals. These island populations are possibly derived from two separate continental migrations. This result is discussed in the context of the history of the African slave trade with respect to Sao Tome and Principe.

Item Type: Article
Uncontrolled Keywords: anopheles gambiae island colonization malaria mitochondrial DNA phylogeography ribosomal DNA s.s. molecular-forms malaria vector west-africa population-structure incipient speciation cladistic-analysis statistical phylogeography geographical-distribution phenotypic associations differentiation
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1752-4571.2008.00048.x
Depositing User: Users 183 not found.
Date Deposited: 10 Aug 2010 09:39
Last Modified: 06 Feb 2018 13:00
URI: https://archive.lstmed.ac.uk/id/eprint/854

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