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Fletcher, Tom, Bleeker-Rovers, Chantal P. and Beeching, Nicholas ORCID: (2017) 'Fever'. Medicine, Vol 45, Issue 3, pp. 177-183.

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and pyrogenic cytokines. Patients with acute fever should be assessed promptly for signs of sepsis. Pyrexia of unknown origin (PUO) is defined as a fever ≥38.3 °C on several occasions over a period of at least 3 weeks, with uncertain diagnosis after a number of obligatory tests. A diagnostic algorithm is outlined in which the most important steps are a thorough history and physical examination, with investigations in a search for potentially diagnostic clues. Scintigraphic methods, such as 67gallium citrate, labelled leucocytes and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), are often used in PUO. The favourable characteristics of FDG-PET/computed tomography mean that conventional scintigraphic techniques are being increasingly replaced by this technique where PET is available. Most patients with undiagnosed PUO have benign self-limiting or recurrent fever.

Item Type: Article
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WB Practice of Medicine > WB 102 Clinical medicine
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 143 Signs and symptoms
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 152 Chills. Fever
WN Radiology. Diagnostic imaging > Nuclear Medicine > WN 440 Nuclear medicine
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 27 Apr 2018 13:21
Last Modified: 09 Sep 2019 06:27


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