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Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state.

Mitsi, Elena, Kamng'ona, Raphael, Rylance, Jamie, SolorzanoGonzalez, Carla, Reiné, Jesús, Mwandumba, Henry, Ferreira, Daniela and Jambo, Kondwani (2018) 'Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state.'. Respiratory Research, Vol 19, Issue 1, p. 66.

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Abstract

Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternatively activated (M2). We investigated the phenotype of human alveolar macrophages (AM) in adults living in two different geographical locations: UK and Malawi. We show that the majority of AM express high levels of M1 and M2 markers simultaneously, with the M1/M2 phenotype being stable in individuals from different geographical locations. The combined M1/M2 features confer to AM a hybrid phenotype, which does not fit the classic macrophage classification. This hybrid phenotype may confer to alveolar macrophages an ability to quickly switch between M1 or M2 associated functions allowing for appropriate responses to stimuli and tissue environment.

Item Type: Article
Subjects: QW Microbiology and Immunology > Reference Works. General Immunology > QW 504 General works
QW Microbiology and Immunology > Immune Responses > QW 640 Agglutination. Precipitation
WF Respiratory System > Lungs > WF 600 Lungs
WH Hemic and Lymphatic Systems > Lymphatic System > WH 650 Reticuloendothelial system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI): https://doi.org/10.1186/s12931-018-0777-0
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 02 May 2018 15:29
Last Modified: 25 May 2018 14:58
URI: http://archive.lstmed.ac.uk/id/eprint/8560

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