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Outcomes of dilation and evacuation with and without feticide by intra-cardiac potassium chloride injection: a service evaluation.

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Lohr, Patricia A, Parsons, John H, Taylor, Jeanette and Morroni, Chelsea ORCID: https://orcid.org/0000-0002-2026-6039 (2018) 'Outcomes of dilation and evacuation with and without feticide by intra-cardiac potassium chloride injection: a service evaluation.'. Contraception, Vol 98, Issue 2, pp. 100-105.

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Abstract

OBJECTIVE
To compare procedure duration, complications, and acceptability of dilation and evacuation (D&E) with and without feticide by intra-cardiac potassium chloride (KCL) injection.

STUDY DESIGN
We evaluated outcomes with D&E at 18-24weeks' gestation in the 6months before and 6months after removing feticide with KCL from the guidelines of a national British abortion provider. We extracted demographic and procedure-related data from medical records and electronic databases. We surveyed women undergoing D&E in both time periods about acceptability and side effects.

RESULTS
We analyzed 291 cases with and 257 cases without KCL. Unadjusted mean procedure duration was shorter with KCL than without (12.7 vs. 16.1min, respectively, p<.001). After adjustment for age, parity, Cesarean deliveries, gestational age, body mass index, surgeon, and number or duration of osmotic dilators used, KCL remained associated with a 3.5min (95% CI 2.4-4.6) reduction in D&E duration. Uterine atony was more common with KCL than without (3% vs. 0%, respectively, p<.001), despite more frequent administration of prophylactic utero-tonics to women who received KCL (82% KCL vs. 73% no-KCL, p=.001). Women who had KCL reported more pain in the period between feticide and dilator placement and the evacuation than women who had not received feticide (49% vs. 25%, respectively, p<.001). Most women in both groups found their procedure very acceptable or acceptable (79% KCL vs. 87% no-KCL, p=.2).

CONCLUSIONS
Feticide with intra-cardiac KCL reduced D&E procedure duration, but was associated with more pain and uterine atony. Treatment acceptability was high with and without feticide.

IMPLICATIONS
Inducing fetal demise before dilation and evacuation with intra-cardiac potassium chloride may result in shorter operative times but does not improve safety or acceptability. Level I evidence remains needed to support the use of feticide before surgical abortion.

Item Type: Article
Subjects: WA Public Health > Health Administration and Organization > WA 550 Family planning
WQ Obstetrics > Childbirth. Prenatal Care > WQ 160 Midwifery
WQ Obstetrics > Pregnancy > WQ 200 General works
WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.contraception.2018.04.010
Depositing User: Stacy Murtagh
Date Deposited: 04 May 2018 10:58
Last Modified: 19 Apr 2019 01:02
URI: http://archive.lstmed.ac.uk/id/eprint/8570

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