LSTM Home > LSTM Research > LSTM Online Archive

Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.

Downloads

Downloads per month over past year

Albers, Lucia, Sobotzki, Christina, Kuß, Oliver, Ajslev, Teresa, Batista, Rosangela Fl, Bettiol, Heloisa, Brabin, Bernard, Buka, Stephen L, Cardoso, Viviane C, Clifton, Vicki L, Devereux, Graham, Gilman, Stephen E, Grzeskowiak, Luke E, Heinrich, Joachim, Hummel, Sandra, Jacobsen, Geir W, Jones, Graeme, Koshy, Gibby, Morgen, Camilla Schmidt, Oken, Emily, Paus, Tomas, Pausova, Zdenka, Rifas-Shiman, Sheryl L, Sharma, Andrea J, da Silva, Antônio Am, Sørensen, Thorkild Ia, Thiering, Elisabeth, Turner, Stephen, Vik, Torstein and von Kries, Rüdiger (2018) 'Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.'. International Journal of Obesity, Vol 42, pp. 1249-1264.

[img] Text
Revised Manuscript_final.docx - Accepted Version

Download (164kB)
[img]
Preview
Image
Figure 1.tif - Supplemental Material

Download (293kB) | Preview
[img]
Preview
Image
Figure 3.tif - Supplemental Material

Download (118kB) | Preview
[img]
Preview
Image
Figure 4.tif - Supplemental Material

Download (1MB) | Preview
[img]
Preview
Image
Figure 5.tif - Supplemental Material

Download (1MB) | Preview
[img]
Preview
Image
Figure S1.tif - Supplemental Material

Download (950kB) | Preview
[img]
Preview
Image
Figure S2.tif - Supplemental Material

Download (961kB) | Preview
[img]
Preview
Image
Figure S3.tif - Supplemental Material

Download (902kB) | Preview
[img]
Preview
Image
Figure S4.tif - Supplemental Material

Download (816kB) | Preview
[img]
Preview
Image
Figure S5.tif - Supplemental Material

Download (870kB) | Preview
[img]
Preview
Image
Figure S6.tif

Download (922kB) | Preview
[img]
Preview
Image
Figure S7.tif - Supplemental Material

Download (845kB) | Preview
[img]
Preview
Image
Figure S8.tif

Download (824kB) | Preview
[img]
Preview
Image
Revised Figure 2.tif

Download (189kB) | Preview
[img] Text
Revised Supplemental Tables.docx - Supplemental Material

Download (43kB)
[img] Text
Revised Figure Legends Supplemental Figures.docx - Supplemental Material

Download (12kB)
[img] Text
Revised Table 1.docx - Supplemental Material

Download (19kB)

Abstract

A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear. Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex. Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results. A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Metabolic Diseases > General Metabolic Diseases > WD 200 General works
WS Pediatrics > WS 100 General works
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 120 In infancy
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 130 In childhood
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1038/s41366-018-0050-0
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 15 May 2018 14:29
Last Modified: 12 Sep 2018 08:03
URI: http://archive.lstmed.ac.uk/id/eprint/8611

Statistics

View details

Actions (login required)

Edit Item Edit Item