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Associated patterns of insecticide resistance in field populations of malaria vectors across Africa.

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Hancock, Penelope A, Wiebe, Antoinette, Gleave, Katherine, Bhatt, Samir, Cameron, Ewan, Trett, Anna, Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Smith, David L, Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Coleman, Michael ORCID: https://orcid.org/0000-0003-4186-3526, Gething, Peter W and Moyes, Catherine L (2018) 'Associated patterns of insecticide resistance in field populations of malaria vectors across Africa.'. Proceedings of the National Academy of Sciences of the United States of America, Vol 115, Issue 231, pp. 5938-5943.

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Abstract

The development of insecticide resistance in African malaria vectors threatens the continued efficacy of important vector control methods that rely on a limited set of insecticides. To understand the operational significance of resistance we require quantitative information about levels of resistance in field populations to the suite of vector control insecticides. Estimation of resistance is complicated by the sparsity of observations in field populations, variation in resistance over time and space at local and regional scales, and cross-resistance between different insecticide types. Using observations of the prevalence of resistance in mosquito species from the complex sampled from 1,183 locations throughout Africa, we applied Bayesian geostatistical models to quantify patterns of covariation in resistance phenotypes across different insecticides. For resistance to the three pyrethroids tested, deltamethrin, permethrin, and λ-cyhalothrin, we found consistent forms of covariation across sub-Saharan Africa and covariation between resistance to these pyrethroids and resistance to DDT. We found no evidence of resistance interactions between carbamate and organophosphate insecticides or between these insecticides and those from other classes. For pyrethroids and DDT we found significant associations between predicted mean resistance and the observed frequency of mutations in the gene in field mosquito samples, with DDT showing the strongest association. These results improve our capacity to understand and predict resistance patterns throughout Africa and can guide the development of monitoring strategies.

Item Type: Article
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1073/pnas.1801826115
Depositing User: Stacy Murtagh
Date Deposited: 25 May 2018 12:41
Last Modified: 07 Jun 2018 09:29
URI: http://archive.lstmed.ac.uk/id/eprint/8681

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