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Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov

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Toe, Kobie, Muller, Pie, Badolo, Athanase, Traore, Alphonse, N'Fale, Sagnon, Dabire, Roch and Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 (2018) 'Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov'. Medical and Veterinary Entomology, Vol 32, Issue 4, pp. 407-416.

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Abstract

Malaria control is dependent on the use of Long Lasting Insecticidal Nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO LLINs) have been developed in response to increasing pyrethroid resistance in African malaria vectors but questions remain about the performance of these nets in areas where pyrethroid resistance is at very high levels. This study was conducted in two settings in Southwest Burkina Faso, Vallée du Kou 5 and Tengrela where Anopheles gambiae s.l. mortality rates in WHO
discriminating dose assays were < 14 % for permethrin < 33 % for
deltamethrin (< 33 %). When mosquitoes were pre-exposed to PBO in WHO tube assays mortality rates increased substantially but full
susceptibility was not restored. Molecular characterisation revealed high levels of kdr alleles and elevated levels of P450s previously implicated in pyrethroid resistance. In cone bioassays and experimental huts the PBO LLINs outperformed the pyrethroid only equivalents from the same manufacturers. Blood feeding rates were 1.6 - 2.2 fold lower, and mortality rates were increased by 1.69 – 1.78 -fold in huts with PBO LLINs versus non PBO LLINs. This study indicates that PBO LLINs provide greater personal and community level protection than standard LLINs against highly pyrethroid resistant mosquito populations.

Item Type: Article
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1111/mve.12316
Depositing User: Daisy Byrne
Date Deposited: 17 Jul 2018 13:13
Last Modified: 29 Nov 2018 11:37
URI: http://archive.lstmed.ac.uk/id/eprint/8742

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